Saturday, 3 March 2012

5.14 Humulin

Understand that large amounts of human insulin can be manufactured from genetically modified bacteria that grow in a fermenter.


  • The bacterial cell containing the recombinant DNA with the human genes (in this case the production of insulin) can be injected into a fermenter and will be necessary to provide it with nutrients, control the temperature and pH and also the gases. 
  • By creating the optimal temperature for bacterial growth, we will see population increase and see the bacteria manufacture protein insulin. 
  • The bacteria inside the fermenter will manufacture the insulin protein from the nutrient (amino acids) provided in the fermenter and it will be necessary to remove the product and carry out purification (called downstream processing) for human usage.
  • The genetically engineered human insulin is called humulin


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